Provera (medroxyprogesterone acetate) tablets

Provera is a synthetic version of the female hormone, progesterone, which prevents ovulation. The active ingredient in Provera is medroxyprogesterone acetate which is administered by injection to prevent pregnancy.

Drug Uses

Provera is a contraceptive to prevent pregnancy. This drug is also used to relieve painful symptoms associated with endometriosis, kidney cancer and metastatic uterine cancer.

Doctors may use Provera to treat other medical conditions.


The Provera injection is usually administered by a doctor or other health care professional. Some patients are permitted to self-inject if the doctor feels that the patient understands exactly how to administer the injection and knows how to dispose of used needles and syringes.

Provera is administered once a week, or every three months, depending on the condition it is being used to treat.

Missed Dose

If a dose is missed, contact your doctor.


Do not use Provera if you are allergic to medroxyprogesterone or if you have breast cancer, abnormal vaginal bleeding, liver disease, or if you have had a blood clot or a stroke.

Ensure that your doctor has a full knowledge of your medical history, including any other medications you are using. These include vitamin supplements, herbal medicines and over-the-counter remedies. Provera can react badly with certain medications.

Provera can cause bone loss which may lead to osteoporosis, particularly when used long-term. Provera should not be used for longer than two years.

Provera does not protect against sexually transmitted diseases.

If a woman becomes pregnant while using Provera, she should inform a doctor immediately.

Provera should be used with caution by women who have diabetes, congestive heart failure, seizures, or a history of depression.

It is not known if Provera is passed into breast milk so women who are breast-feeding should discuss the risks of using Provera with a doctor.

While using Provera you will need to have regular check-ups with your doctor.


Call for emergency medical assistance if any of the following allergic symptoms occur: difficulty in breathing, hives, or swelling of the lips, face, tongue or throat.

Contact your doctor if you have any of the following serious side-effects: sudden headache, sudden weakness or numbness on one side of the body, vision problems, speech problems, confusion, unsteadiness, jaundice, fever, swelling (feet, hands, ankles), insomnia, depression, or mood swings.

Less serious side-effects may include headache, nervousness, dizziness, fatigue, change in menstrual cycle, breast discharge or tenderness, mild stomach pain, change in appetite or weight, nausea, bloating, back or pelvic pain, mild skin rash or itching, acne, hair loss, insomnia, vaginal discharge or itching, or decreased libido.

This is not a complete list of side effects. If any other uncomfortable symptoms occur and persist, contact your doctor.


This is only likely to occur if you are self-injecting. If overdose is suspected, call for emergency medical assistance immediately.


If Provera is kept at home, it should be stored in a cool, dry place away from sun and moisture.